Molecular Allostery in Dengue NS3 Helicase along the ATP Hydrolysis Cycle
نویسندگان
چکیده
منابع مشابه
Novel ATP-Independent RNA Annealing Activity of the Dengue Virus NS3 Helicase
The flavivirus nonstructural protein 3 (NS3) bears multiple enzymatic activities and represents an attractive target for antiviral intervention. NS3 contains the viral serine protease at the N-terminus and ATPase, RTPase, and helicase activities at the C-terminus. These activities are essential for viral replication; however, the biological role of RNA remodeling by NS3 helicase during the vira...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2017
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2016.11.2689